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KMID : 1161420200230080870
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Journal of Medicinal Food
2020 Volume.23 No. 8 p.870 ~ p.878
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Rose Petal Extract (Rosa gallica) Exerts Skin Whitening and Anti-Skin Wrinkle Effects
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Song Young-Ran
Lim Won-Chul
Han Ah-Ram
Lee Myung-Hee
Shin Eun-Ju
Lee Kwang-Min
Nam Tae-Gyu
Lim Tae-Gyu
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Abstract
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We sought to investigate the effect of extracts from Rosa gallica petals (RPE) on skin whitening and anti-wrinkle activity. Tyrosinase activity was attenuated by RPE treatment, concomitant with the reduction of melanin accumulation in human B16F10 melanoma. Treatment of the facial skin of volunteers in a clinical trial with an RPE-containing formulation enhanced skin brightness (L* value) significantly. The underlying mechanism responsible was determined to be associated with mitogen-activated protein kinase (MAPK) activation. In addition, RPE exhibited anti-wrinkle formation activity of human dermal fibroblasts by suppressing matrix metalloproteinase (MMP)-1 level. In vivo study, RPE also inhibited solar ultraviolet-stimulated MMP-1 level by c-Jun regulation. Overall, our findings indicate that RPE evokes skin whitening and anti-wrinkle formation activity by regulating intracellular signaling, supporting its utility as an ingredient for skin whitening and anti-wrinkle cosmetic products.
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KEYWORD
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melanin, MMP-1, Rosa gallica, skin whitening, wrinkle formation
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